KI696 (Standard)

• Description:

  KI696 (Standard) is the analytical standard of KI696 (HY-101140) . This product is intended for research and analytical applications. KI696 is a high affinity probe that disrupts the Keap1/NRF2 interaction. KI696 is a potent and selective inhibitor of the KEAP1/NRF2 interaction[1].

• Target:

  Keap1-Nrf2; Reference Standards

• Related Pathways:

  NF-κB; Others

• Field of Research:

  Metabolic Disease; Inflammation/Immunology

• Smiles:

  COC1=C (N2C) C (N=N2) =CC ([C@H] (C3=CC (CN (C[C@H]4C) S (=O) (C5=CC=CC=C5O4) =O) =C (C) C=C3) CC (O) =O) =C1

• Molecular Formula:

  C28H30N4O6S

• Molecular Weight:

  550.63

• References & Citations:

  [1]Davies TG, et al. Monoacidic Inhibitors of the Kelch-like ECH-Associated Protein 1: Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1:NRF2) Protein-Protein Interaction with High Cell Potency Identified by Fragment-Based Discovery. J Med Chem. 2016 Apr 28;59 (8) :3991-4006.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference Standards

• CAS Number:

  1799974-70-1