KI696

• Description :

  KI696 is a high affinity probe that disrupts the Keap1/NRF2 interaction. KI696 is a potent and selective inhibitor of the KEAP1/NRF2 interaction[1].

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Keap1-Nrf2

• Type :

  Reference compound

• Related Pathways :

  NF-κB

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Metabolic Disease; Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/KI696.html

• Purity :

  99.26

• Solubility :

  DMSO : 50 mg/mL (ultrasonic)

• Smiles :

  COC1=C(N2C)C(N=N2)=CC([C@H](C3=CC(CN(C[C@H]4C)S(=O)(C5=CC=CC=C5O4)=O)=C(C)C=C3)CC(O)=O)=C1

• Molecular Formula :

  C28H30N4O6S

• Molecular Weight :

  550.63

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Davies TG, et al. Monoacidic Inhibitors of the Kelch-like ECH-Associated Protein 1: Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1:NRF2) Protein-Protein Interaction with High Cell Potency Identified by Fragment-Based Discovery. J Med Chem. 2016 Apr 28;59 (8) :3991-4006.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1799974-70-1]