KI696

• Description:

  KI696 is a high affinity probe that disrupts the Keap1/NRF2 interaction. KI696 is a potent and selective inhibitor of the KEAP1/NRF2 interaction[1].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Keap1-Nrf2

• Type:

  Reference compound

• Related Pathways:

  NF-κB

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Metabolic Disease; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/KI696.html

• Purity:

  99.26

• Solubility:

  DMSO : 50 mg/mL (ultrasonic)

• Smiles:

  COC1=C (N2C) C (N=N2) =CC ([C@H] (C3=CC (CN (C[C@H]4C) S (=O) (C5=CC=CC=C5O4) =O) =C (C) C=C3) CC (O) =O) =C1

• Molecular Formula:

  C28H30N4O6S

• Molecular Weight:

  550.63

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Davies TG, et al. Monoacidic Inhibitors of the Kelch-like ECH-Associated Protein 1: Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1:NRF2) Protein-Protein Interaction with High Cell Potency Identified by Fragment-Based Discovery. J Med Chem. 2016 Apr 28;59 (8) :3991-4006.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  1799974-70-1