ML-9 (Standard)

• Description:

  ML-9 (Standard) is the analytical standard of ML-9 (HY-100932) . This product is intended for research and analytical applications. ML-9 is a selective and potent inhibitor of Akt kinase, inhibits myosin light-chain kinase (MLCK) and stromal interaction molecule 1 (STIM1) activity[3]. ML-9 inhibits inhibits MLCK, PKA and PKC activity with Ki values of 4, 32 and 54 μM, respectively[1]. ML-9 induces autophagy by stimulating autophagosome formation and inhibiting their degradation[3].

• Target:

  Myosin; Reference Standards

• Related Pathways:

  Cytoskeleton; Others

• Field of Research:

  Cancer

• Smiles:

  O=S (N1CCNCCC1) (C2=C3C=CC=C (Cl) C3=CC=C2) =O.[H]Cl

• Molecular Formula:

  C15H18Cl2N2O2S

• Molecular Weight:

  361.29

• References & Citations:

  [1]Ito S, et al. ML-9, a myosin light chain kinase inhibitor, reduces intracellular Ca2+ concentration in guinea pig trachealis.Eur J Pharmacol. 2004 Feb 23;486 (3) :325-33.|[2]Shaikh S, et al. The STIM1 inhibitor ML9 disrupts basal autophagy in cardiomyocytes by decreasing lysosome content.Toxicol In Vitro. 2018 Apr;48:121-127.|[3]Kondratskyi A1, et al.Identification of ML-9 as a lysosomotropic agent targeting autophagy and cell death.Cell Death Dis. 2014 Apr 24;5:e1193.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference Standards

• CAS Number:

  105637-50-1