Ticagrelor-d4

• Description :

  Ticagrelor-d4 (AZD6140-d4) is deuterium labeled Ticagrelor. Ticagrelor (AZD6140) is a reversible oral P2Y12 receptor antagonist for the treatment of platelet aggregation.

• Product Name Alternative :

  AZD6140-d4; AR-C 126532XX-d4

• UNSPSC :

  12352005

• Target :

  Isotope-Labeled Compounds; P2Y Receptor

• Related Pathways :

  GPCR/G Protein; Others

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cardiovascular Disease; Cancer

• Smiles :

  OC([2H])([2H])C([2H])([2H])O[C@H]([C@H]([C@H]1O)O)C[C@H]1N2C3=NC(SCCC)=NC(N[C@H]4[C@H](C5=CC(F)=C(C=C5)F)C4)=C3N=N2

• Molecular Formula :

  C23H24D4F2N6O4S

• Molecular Weight :

  526.59

• References & Citations :

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Aungraheeta R, et al. Inverse agonism at the P2Y12 receptor and ENT1 transporter blockade contribute to platelet inhibition by ticagrelor. Blood. 2016 Dec 8;128 (23) :2717-2728.|[3]Gebremeskel S, et al. The reversible P2Y12 inhibitor ticagrelor inhibits metastasis and improves survival in mouse models of cancer. Int J Cancer. 2015 Jan 1;136 (1) :234-40.|[4]Sugidachi A, et al. A comparison of the pharmacological profiles of prasugrel and ticagrelor assessed by platelet aggregation, thrombus formation and haemostasis in rats. Br J Pharmacol. 2013 May;169 (1) :82-9.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Isotope-Labeled Compounds

• Clinical Information :

  No Development Reported

• CAS Number :

  [1265911-54-3]