C29 (Standard)

CAT: 0804-HY-100461RSize: 1 EachDry Ice: NoHazardous: No

CAT#:0804-HY-100461RSize:1 Each

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Description

C29 (Standard) is the analytical standard of C29 (HY-100461) . This product is intended for research and analytical applications. C29 is a Toll-like receptor 2 (TLR2) inhibitor. C29 blocks hTLR2/1 and hTLR2/6 signaling with IC50s of 19.7 and 37.6 μM, respectively[1].

CAS Number

[363600-92-4]

Target

Reference Standards; Toll-like Receptor (TLR)

Related Pathways

Immunology/Inflammation; Others

Field of Research

Inflammation/Immunology

Smiles

OC1=C(/C=N/C2=C(C)C(C(O)=O)=CC=C2)C=CC=C1OC

Molecular Formula

C16H15NO4

Molecular Weight

285.29

References & Citations

[1]Mistry P, et al. Inhibition of TLR2 signaling by small molecule inhibitors targeting a pocket within the TLR2 TIR domain. Proc Natl Acad Sci U S A. 2015 Apr 28;112 (17) :5455-60.|[2]Cai S, Zhu G, Cen X, et al. Synthesis, structure-activity relationships and preliminary mechanism study of N-benzylideneaniline derivatives as potential TLR2 inhibitors. Bioorg Med Chem. 2018;26 (8) :2041-2050.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

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