C29 (Standard)

• Description:

  C29 (Standard) is the analytical standard of C29 (HY-100461) . This product is intended for research and analytical applications. C29 is a Toll-like receptor 2 (TLR2) inhibitor. C29 blocks hTLR2/1 and hTLR2/6 signaling with IC50s of 19.7 and 37.6 μM, respectively[1].

• Target:

  Reference Standards; Toll-like Receptor (TLR)

• Related Pathways:

  Immunology/Inflammation; Others

• Field of Research:

  Inflammation/Immunology

• Smiles:

  OC1=C(/C=N/C2=C(C)C(C(O)=O)=CC=C2)C=CC=C1OC

• Molecular Formula:

  C16H15NO4

• Molecular Weight:

  285.29

• References & Citations:

  [1]Mistry P, et al. Inhibition of TLR2 signaling by small molecule inhibitors targeting a pocket within the TLR2 TIR domain. Proc Natl Acad Sci U S A. 2015 Apr 28;112 (17) :5455-60.|[2]Cai S, Zhu G, Cen X, et al. Synthesis, structure-activity relationships and preliminary mechanism study of N-benzylideneaniline derivatives as potential TLR2 inhibitors. Bioorg Med Chem. 2018;26 (8) :2041-2050.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference Standards

• CAS Number:

  [363600-92-4]