C29

• Description:

  C29 is a Toll-like receptor 2 (TLR2) inhibitor. C29 blocks hTLR2/1 and hTLR2/6 signaling with IC50s of 19.7 and 37.6 μM, respectively[1].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H312, H332

• Target:

  Toll-like Receptor (TLR)

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/C29.html

• Purity:

  98.00

• Solubility:

  DMSO : ≥ 30 mg/mL

• Smiles:

  OC1=C(/C=N/C2=C(C)C(C(O)=O)=CC=C2)C=CC=C1OC

• Molecular Formula:

  C16H15NO4

• Molecular Weight:

  285.29

• Precautions:

  H302, H312, H332

• References & Citations:

  [1]Mistry P, et al. Inhibition of TLR2 signaling by small molecule inhibitors targeting a pocket within the TLR2 TIR domain. Proc Natl Acad Sci U S A. 2015 Apr 28;112 (17) :5455-60.|[2]Cai S, Zhu G, Cen X, et al. Synthesis, structure-activity relationships and preliminary mechanism study of N-benzylideneaniline derivatives as potential TLR2 inhibitors. Bioorg Med Chem. 2018;26 (8) :2041-2050.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  TLR2

• CAS Number:

  [363600-92-4]