C29

CAT: 0804-HY-100461-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-100461-01Size:1 mg
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Description
C29 is a Toll-like receptor 2 (TLR2) inhibitor. C29 blocks hTLR2/1 and hTLR2/6 signaling with IC50s of 19.7 and 37.6 μM, respectively[1].
CAS Number
[363600-92-4]
UNSPSC
12352005
Hazard Statement
H302, H312, H332
Target
Toll-like Receptor (TLR)
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/C29.html
Purity
98.00
Solubility
DMSO : ≥ 30 mg/mL
Smiles
OC1=C(/C=N/C2=C(C)C(C(O)=O)=CC=C2)C=CC=C1OC
Molecular Formula
C16H15NO4
Molecular Weight
285.29
Precautions
H302, H312, H332
References & Citations
[1]Mistry P, et al. Inhibition of TLR2 signaling by small molecule inhibitors targeting a pocket within the TLR2 TIR domain. Proc Natl Acad Sci U S A. 2015 Apr 28;112 (17) :5455-60.|[2]Cai S, Zhu G, Cen X, et al. Synthesis, structure-activity relationships and preliminary mechanism study of N-benzylideneaniline derivatives as potential TLR2 inhibitors. Bioorg Med Chem. 2018;26 (8) :2041-2050.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TLR2

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