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AEE788 (Standard)

CAT: 0804-HY-10045RSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-10045RSize:1 Each
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Description
AEE788 (Standard) is the analytical standard of AEE788. This product is intended for research and analytical applications. AEE788 is an inhibitor of the EGFR and ErbB2 with IC50 values of 2 and 6 nM, respectively.
CAS Number
497839-62-0
Target
Apoptosis; EGFR; Reference Standards
Related Pathways
Apoptosis; JAK/STAT Signaling; Others; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
C[C@H](C1=CC=CC=C1)NC2=C(C=C3C(C=C4)=CC=C4CN5CCN(CC)CC5)C(N3)=NC=N2
Molecular Formula
C27H32N6
Molecular Weight
440.58
References & Citations
[1]Traxler P, et al. AEE788: a dual family epidermal growth factor receptor/ErbB2 and vascular endothelial growth factor receptor tyrosine kinase inhibitor with antitumor and antiangiogenic activity. Cancer Res. 2004 Jul 15;64 (14) :4931-4941.|[2]Park et al. AEE788, a dual tyrosine kinase receptor inhibitor, induces endothelial cell apoptosis in human cutaneous squamous cell carcinoma xenografts in nude mice. Clin Cancer Res. 2005 Mar 1;11 (5) :1963-1973.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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