AEE788

• Description :

  AEE788 is an inhibitor of the EGFR and ErbB2 with IC50 values of 2 and 6 nM, respectively.

• CAS Number :

  [497839-62-0]

• Product Name Alternative :

  NVP-AEE 788

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Apoptosis; EGFR

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/AEE788.html

• Purity :

  98.39

• Solubility :

  DMSO : 50 mg/mL (ultrasonic)

• Smiles :

  C[C@H](C1=CC=CC=C1)NC2=C(C=C3C(C=C4)=CC=C4CN5CCN(CC)CC5)C(N3)=NC=N2

• Molecular Formula :

  C27H32N6

• Molecular Weight :

  440.58

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Traxler P, et al. AEE788: a dual family epidermal growth factor receptor/ErbB2 and vascular endothelial growth factor receptor tyrosine kinase inhibitor with antitumor and antiangiogenic activity. Cancer Res. 2004 Jul 15;64 (14) :4931-4941.|[2]Park et al. AEE788, a dual tyrosine kinase receptor inhibitor, induces endothelial cell apoptosis in human cutaneous squamous cell carcinoma xenografts in nude mice. Clin Cancer Res. 2005 Mar 1;11 (5) :1963-1973.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 2

• Isoform :

  EGFR/ErbB1/HER1; ErbB2/HER2