Products for Research Use Only
RegisterLogin

Pactimibe (sulfate) (Standard)

CAT: 0804-HY-100401ARSize: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-100401ARSize:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Pactimibe (sulfate) (Standard) is the analytical standard of Pactimibe (sulfate). This product is intended for research and analytical applications. Pactimibe sulfate (CS-505) is a dual ACAT1/2 inhibitor with IC50s of 4.9 μM and 3.0 μM, respectively. Pactimibe sulfate (CS-505) inhibits ACAT with IC50s of 2.0 μM, 2.7 μM, 4.7 μM in the liver, macrophages and THP-1 cells, respectively[1]. Pactimibe sulfate (CS-505) noncompetitively inhibits oleoyl-CoA with a Ki value of 5.6 μM. Moreover, Pactimibe sulfate (CS-505) obviously inhibits cholesteryl ester formation with an IC50 of 6.7 μM. Pactimibe sulfate (CS-505) possesses anti-atherosclerotic potential with lowering plasma cholesterol activity[2].
CAS Number
608510-47-0
Target
Acyltransferase; Reference Standards
Related Pathways
Metabolic Enzyme/Protease; Others
Field of Research
Cardiovascular Disease
Smiles
O=C(O)CC1=C(C)C2=C(N(CCCCCCCC)CC2)C(NC(C(C)(C)C)=O)=C1C.O=S(O)(O)=O.[1/2]
Molecular Formula
C25H40N2O3.1/2H2O4S
Molecular Weight
465.65
References & Citations
[1]Naoki Terasaka, et al. ACAT inhibitor pactimibe sulfate (CS-505) reduces and stabilizes atherosclerotic lesions by cholesterol-lowering and direct effects in apolipoprotein E-deficient mice. Atherosclerosis. 2007 Feb;190 (2) :239-47.|[2]Ken Kitayama, et al. Importance of acyl-coenzyme A:cholesterol acyltransferase 1/2 dual inhibition for anti-atherosclerotic potency of pactimibe. Eur J Pharmacol. 2006 Jul 1;540 (1-3) :121-30.|[3]Yasunobu Yoshinaka, et al. A selective ACAT-1 inhibitor, K-604, stimulates collagen production in cultured smooth muscle cells and alters plaque phenotype in apolipoprotein E-knockout mice. Atherosclerosis. 2010 Nov;213 (1) :85-91.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

Related Products

CatalogName
HY-100401A-01Pactimibe (sulfate)
HY-100401-01Pactimibe
HY-N0716BR-01Berberine (sulfate) (Standard)
HY-B1241R-01Dihydrostreptomycin (sulfate) (Standard)
HY-101406RThyroxine sulfate (Standard)
HY-50706AR-01Selumetinib (sulfate) (Standard)
HY-100799RZAPA (sulfate) (Standard)
HY-10119ARVorapaxar (sulfate) (Standard)
HY-B1205AR-01Atropine (sulfate) (Standard)
HY-A0276RGentamicin (sulfate) (Standard)

Alternative Products

CatalogName
T62974-01Pactimibe sulfate
TRC-P156450-50MGPactimibe Sulfate (2:1)
ASSO492YSulfate Standard for Ion Chromatography
AS-SO4S9-2YSulfate-Sulfur Standard for Ion Chromatography
C135-125ULEstrone-3-Sulfate (E1S) Standard, 125UL
C135-625ULEstrone-3-Sulfate (E1S) Standard, 625UL
CPPB01Reagecon Cupric Sulfate Standard Solution according to Chinese Pharmacopoeia (ChP)
MBS2102010-01Human Heparan Sulfate Proteoglycan 2 (HSPG2) Antibody Pair Kit (with Standard)
CS-O-46813ENDOSULFAN SULFATE ORGANIC STANDARD, 1,000 UG/ML IN METHANOL - 1ML
MBS2099962-01Rat Chondroitin Sulfate Proteoglycan 5 (CSPG5) Antibody Pair Kit (with Standard)

Popular Products