Products for Research Use Only
RegisterLogin

SHP099 (Standard)

CAT: 0804-HY-100388R-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-100388R-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
SHP099 (Standard) is the analytical standard of SHP099. This product is intended for research and analytical applications. SHP099 is an allosteric SHP2 inhibitor, with IC50s of 0.690, 1.241, 0.416, 1.968, 2.896 μM for SHP2, SHP2D61Y, SHP2E69K, SHP2A72V, SHP2E76K. SHP099 inhibits cancer cell growth, such as MV4-11 and TF-1 cell (IC50: 0.32 and 1.73 μM) . SHP099 inhibits RAS-ERK signaling and inhibits tumor growth[1][2].
CAS Number
1801747-42-1
UNSPSC
12352005
Target
Phosphatase; Reference Standards; SHP2
Related Pathways
Metabolic Enzyme/Protease; Others; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
NC1=NC(N2CCC(C)(N)CC2)=CN=C1C3=CC=CC(Cl)=C3Cl
Molecular Formula
C16H19Cl2N5
Molecular Weight
352.26
References & Citations
[1]Chen YN, et al. Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases. Nature. 2016 Jul 7;535 (7610) :148-52.|[2]Sun X, et al. Selective inhibition of leukemia-associated SHP2E69K mutant by the allosteric SHP2 inhibitor SHP099. Leukemia. 2018 May;32 (5) :1246-1249.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

Related Products

CatalogName
HY-100388AR-01SHP099 (monohydrochloride) (Standard)
HY-100388-01SHP099
HY-100388BSHP099 (hydrochloride)
HY-100388A-01SHP099 (monohydrochloride)
HY-P2274RArgifin (Standard)
HY-N9362REmodinanthrone (Standard)
HY-N7948RIsomaltotetraose (Standard)
HY-N7640RDeoxylimonin (Standard)
HY-N7617RToralactone (Standard)
HY-N7541RAntrodin A (Standard)

Alternative Products

CatalogName
BXC74742-01SHP099
AND21493-01SHP099 hydrochloride
A20594-10SHP099 10mg
M28039-01SHP099 monohydrochloride
S8278-100mgSHP099 HCl
A20594-25SHP099 25mg

Popular Products