C12-Ceramide (Standard)

• Description:

  C12-Ceramide (Standard) is the analytical standard of C12-Ceramide. This product is intended for research and analytical applications. C12-Ceramide (N-Lauroyl-D-erythro-sphingosine), a naturally occurring ceramide, is formed by hydrolysis of C12 sphingomyelin. C12-Ceramide can enhance the Doxorubicin toxicity in MDA-MB-231 cells. C12-Ceramide also can be used to diagnose types A and B Niemann-Pick disease[1][1].

• Product Name Alternative:

  N-Lauroyl-D-erythro-sphingosine (Standard) ; N-Laurylsphingosine (Standard)

• UNSPSC:

  12352211

• Target:

  Others; Reference Standards

• Related Pathways:

  Others

• Field of Research:

  Cancer; Metabolic Disease

• Smiles:

  CCCCCCCCCCCC(N[C@@H](CO)[C@H](O)/C=C/CCCCCCCCCCCCC)=O

• Molecular Formula:

  C30H59NO3

• Molecular Weight:

  481.79

• References & Citations:

  [1]He X, et, al. A fluorescence-based, high-performance liquid chromatographic assay to determine acid sphingomyelinase activity and diagnose types A and B Niemann-Pick disease. Anal Biochem. 2003 Mar 1;314 (1) :116-20.|[2]Øverbye A, et, al. Ceramide-containing liposomes with doxorubicin: time and cell-dependent effect of C6 and C12 ceramide. Oncotarget. 2017 Aug 12;8 (44) :76921-76934.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference Standards

• CAS Number:

  [74713-60-3]