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FR194738 (Standard)

CAT: 0804-HY-100303ARSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-100303ARSize:1 Each
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Description
FR194738 (Standard) is the analytical standard of FR194738. This product is intended for research and analytical applications. FR194738 is a squalene epoxidase inhibitor. FR194738 inhibits squalene epoxidase activity in HepG2 cell homogenates with an IC50 of 9.8 nM.
CAS Number
204067-52-7
Target
Others; Reference Standards
Related Pathways
Others
Field of Research
Metabolic Disease
Smiles
CC(OCC1=CSC=C1)(C)COC2=CC(CN(C/C=C/C#CC(C)(C)C)CC)=CC=C2.Cl
Molecular Formula
C27H38ClNO2S
Molecular Weight
476.11
References & Citations
[1]Sawada M, et al. Effect of FR194738, a potent inhibitor of squalene epoxidase, on cholesterol metabolism in HepG2 cells. Eur J Pharmacol. 2001 Nov 9;431 (1) :11-6.|[2]Sawada M, et al. Synthesis and biological activity of a novel squalene epoxidase inhibitor, FR194738. Bioorg Med Chem Lett. 2004 Feb 9;14 (3) :633-7.|[3]Sawada M, et al. Inhibition of cholesterol synthesis causes both hypercholesterolemia and hypocholesterolemia in hamsters. Biol Pharm Bull. 2002 Dec;25 (12) :1577-82.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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T11320-01FR194738
A21744-50FR194738 50mg
A21744-10FR194738 10mg
A21744-100FR194738 100mg
A21744-1FR194738 1mg
A21744-25FR194738 25mg
A21744-5FR194738 5mg
T11321-01FR194738 free base
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