Tubercidin (Standard)

• Description:

  Tubercidin (Standard) is the analytical standard of Tubercidin. This product is intended for research and analytical applications. Tubercidin (7-Deazaadenosine) is an antibiotic obtained from Streptomyces tubercidicus. Tubercidin inhibits the growth of Streptococcus faecalis (8043) with an IC50 of 0.02 μM[1]. Tubercidin inhibits polymerases by incorporating DNA or RNA, thereby inhibiting DNA replication, RNA and protein synthesis[2]. Tubercidin is a weak inhibitor of adenosine phosphorylase, and interferes with the phosphorylation of adenosine and AMP[1]. Tubercidin has antiviral activity[2].

• Product Name Alternative:

  7-Deazaadenosine (Standard)

• UNSPSC:

  12352005

• Target:

  Antibiotic; Bacterial; DNA/RNA Synthesis; Influenza Virus; Reference Standards

• Related Pathways:

  Anti-infection; Cell Cycle/DNA Damage; Others

• Field of Research:

  Infection

• Smiles:

  O[C@H]1[C@@H] (O) [C@H] (N2C=CC3=C2N=CN=C3N) O[C@@H]1CO

• Molecular Formula:

  C11H14N4O4

• Molecular Weight:

  266.26

• References & Citations:

  [1]Bloch A, et al. On the mode of action of 7-deaza-adenosine (Tubercidin) . Biochim Biophys Acta. 1967 Mar 29;138 (1) :10-25.|[2]Kouni MH, et al. Prevention of tubercidin host toxicity by nitrobenzylthioinosine 5'-monophosphate for the treatment of schistosomiasis. Antimicrob Agents Chemother. 1989 Jun;33 (6) :824-7.|[3]Bergstrom DE, et al. Antiviral activity of C-5 substituted tubercidin analogues. J Med Chem. 1984 Mar;27 (3) :285-92.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference Standards

• CAS Number:

  69-33-0