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Sinapinic acid

CAT: 0804-HY-W009732-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0804-HY-W009732-01Size:1 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Sinapinic acid (Sinapic acid) is a phenolic compound isolated from Hydnophytum formicarum Jack. Rhizome, acts as an inhibitor of HDAC, with an IC50 of 2.27 mM[1], and also inhibits ACE-I activity[2]. Sinapinic acid posssess potent anti-tumor activity, induces apoptosis of tumor cells[1]. Sinapinic acid shows antioxidant and antidiabetic activities[2]. Sinapinic acid reduces total cholesterol, triglyceride, and HOMA-IR index, and also normalizes some serum parameters of antioxidative abilities and oxidative damage in ovariectomized rats[3].
CAS Number
530-59-6
Product Name Alternative
Sinapic acid
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Angiotensin-converting Enzyme (ACE) ; Apoptosis; HDAC; Reactive Oxygen Species (ROS)
Type
Natural Products
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer; Metabolic Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/Sinapinic_acid.html
Concentration
10mM
Purity
99.95
Solubility
DMSO : 50 mg/mL (ultrasonic) |Ethanol : 25 mg/mL (ultrasonic)
Smiles
COC1=C(O)C(OC)=CC(/C=C/C(O)=O)=C1
Molecular Formula
C11H12O5
Molecular Weight
224.21
Precautions
H315, H319, H335
References & Citations
[1]Senawong T, et al. Histone deacetylase (HDAC) inhibitory and antiproliferative activities of phenolic-rich extracts derived from the rhizome of Hydnophytum formicarum Jack.: sinapinic acid acts as HDAC inhibitor. BMC Complement Altern Med. 2013 Sep 22;13:232.|[2]Quinn L, et al. Extraction and Quantification of Sinapinic Acid from Irish Rapeseed Meal and Assessment of Angiotensin-I Converting Enzyme (ACE-I) Inhibitory Activity. J Agric Food Chem. 2017 Aug 16;65 (32) :6886-6892.|[3]Zych M, et al. The Effects of Sinapic Acid on the Development of Metabolic Disorders Induced by Estrogen Deficiency in Rats. Oxid Med Cell Longev. 2018 Jun 4;2018:9274246.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
HDAC

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