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Rabbit Polyclonal Antibody to LYAR

CAT: 1725-P10419-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:1725-P10419-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Plays a role in the maintenance of the appropriate processing of 47S/45S pre-rRNA to 32S/30S pre-rRNAs and their subsequent processing to produce 18S and 28S rRNAs (PubMed:24495227) . Also acts at the level of transcription regulation. Along with PRMT5, binds the gamma-globin (HBG1/HBG2) promoter and represses its expression (PubMed:25092918) . In neuroblastoma cells, may also repress the expression of oxidative stress genes, including CHAC1, HMOX1, SLC7A11, ULBP1 and SNORD41 that encodes a small nucleolar RNA (PubMed:28686580) . Preferentially binds to a DNA motif containing 5'-GGTTAT-3' (PubMed:25092918) . Stimulates phagocytosis of photoreceptor outer segments by retinal pigment epithelial cells (By similarity) . Prevents nucleolin/NCL self-cleavage, maintaining a normal steady-state level of NCL protein in undifferentiated embryonic stem cells (ESCs), which in turn is essential for ESC self-renewal (By similarity) .
Product Name Alternative
ZLYAR; ZC2HC2
Swiss Prot
Q9NX58
Host
Rabbit
Reactivity
Human
Immunogen
Fusion protein of human LYAR
Clonality
Polyclonal
Applications
WB, IHC
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Formulation
Purified antibody in PBS with 0.05% sodium azide and 50% glycerol.
Antibody Type
Primary antibody
Protein Name
LYAR
Bands Size
44 kDa

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