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Rabbit Polyclonal Antibody to CBFA2T2

CAT: 1725-P10199-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:1725-P10199-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
In acute myeloid leukemia, especially in the M2 subtype, the t (8;21) (q22; q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described.
Product Name Alternative
EHT; p85; MTGR1; ZMYND3
Swiss Prot
O43439
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Fusion protein of human CBFA2T2
Clonality
Polyclonal
Applications
WB
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Formulation
Purified antibody in PBS with 0.05% sodium azide and 50% glycerol.
Antibody Type
Primary antibody
Protein Name
CBFA2T2
Bands Size
67 kDa

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