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Rabbit Polyclonal Antibody to ECD

CAT: 1725-P09936-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:1725-P09936-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Regulator of p53/TP53 stability and function. Inhibits MDM2-mediated degradation of p53/TP53 possibly by cooperating in part with TXNIP (PubMed:16849563, PubMed:23880345) . May be involved transcriptional regulation. In vitro has intrinsic transactivation activity enhanced by EP300. May be a transcriptional activator required for the expression of glycolytic genes (PubMed:19919181, PubMed:9928932) . Involved in regulation of cell cycle progression. Proposed to disrupt Rb-E2F binding leading to transcriptional activation of E2F proteins (PubMed:19640839) . The cell cycle -regulating function may depend on its RUVBL1-mediated association with the R2TP complex (PubMed:26711270) . May play a role in regulation of pre-mRNA splicing (PubMed:24722212) .
Product Name Alternative
GCR2; SGT1; HSGT1
Swiss Prot
O95905
Host
Rabbit
Reactivity
Human
Immunogen
Fusion protein of human ECD
Clonality
Polyclonal
Applications
WB, IHC
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Formulation
Purified antibody in PBS with 0.05% sodium azide and 50% glycerol.
Antibody Type
Primary antibody
Protein Name
ECD
Bands Size
73 kDa

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