MK-2206 (dihydrochloride)

MK-2206 (dihydrochloride)

• CAS Number: 1032350-13-2
• UNSPSC Description: MK-2206 dihydrochloride (MK-2206 (2HCl)) is an orally active, BBB-penetrated allosteric AKT inhibitor with IC50s of 5 nM, 12 nM, and 65 nM for AKT1, AKT2, and AKT3, respectively. MK-2206 dihydrochloride induces autophagy[1][2].
• Target Antigen: Akt; Apoptosis; Autophagy; Organoid
• Type: Reference compound
• Related Pathways: Apoptosis;Autophagy;PI3K/Akt/mTOR;Stem Cell/Wnt
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/MK-2206-dihydrochloride.html
• Purity: 99.99
• Solubility: DMSO : 12.5 mg/mL (ultrasonic;warming;heat to 60°C)|H2O : 3.57 mg/mL (ultrasonic;warming;heat to 60°C)
• Smiles: O=C1N2C(C3=CC(C4=CC=CC=C4)=C(N=C3C=C2)C5=CC=C(C6(N)CCC6)C=C5)=NN1.Cl.Cl
• Molecular Weight: 480.39
• References & Citations: [1]Zhao YY, et al. Effects of an oral allosteric AKT inhibitor (MK-2206) on human nasopharyngeal cancer in vitro and in vivo. Drug Des Devel Ther. 2014 Oct 10;8:1827-37.|[2]Agarwal E, et al. Akt inhibitor MK-2206 promotes anti-tumor activity and cell death by modulation of AIF and Ezrin in colorectal cancer. BMC Cancer. 2014 Mar 1;14:145.|[3]Li Yan, et al. 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• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, sealed storage, away from moisture)
• Clinical Information: Phase 2