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Rabbit Polyclonal Antibody to MBD2

CAT: 1725-P06256-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:1725-P06256-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD) . Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing. Two transcript variants encoding different isoforms have been found for this gene.
Product Name Alternative
DMTase; NY-CO-41
Swiss Prot
Q9UBB5
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Synthetic peptide of human MBD2
Clonality
Polyclonal
Applications
WB, IHC
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Formulation
Purified antibody in PBS with 0.05% sodium azide and 50% glycerol.
Antibody Type
Primary antibody
Protein Name
MBD2
Bands Size
43 kDa

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