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Rabbit Polyclonal Antibody to CD5

CAT: 1725-P06155-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:1725-P06155-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CD5 (also designated Lyt-1) has been identified as a transmembrane glycoprotein that is expressed on 70% of normal peripheral blood lymphocytes and on virtually all T lymphocytes in thymus and peripheral blood. Activation of T cells through the T cell receptor (TCR) results in tyrosine phosphorylation of CD5, and the absence of CD5 renders T cells hyper-responsive to TCR-mediated activation. CD5 associates with the TCR/ CD3-ζ chain and with the Src family kinase Lck p56. In vitro studies have shown a 10- to 15-fold increase in the kinase activity of Lck bound to CD5. The B cell antigen, CD72, serves as a receptor for CD5. The consequence of CD5 binding to its cognate receptor is still in question and likely plays a role in thymic selection. May act as a receptor in regulating T-cell proliferation.
Product Name Alternative
T1; LEU1
Swiss Prot
P06127
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide of human CD5
Clonality
Polyclonal
Applications
IHC
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Formulation
Purified antibody in PBS with 0.05% sodium azide and 50% glycerol.
Antibody Type
Primary antibody
Protein Name
CD5

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