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Rabbit Polyclonal Antibody to BORA

CAT: 1725-P06070-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:1725-P06070-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Aurora related kinase-1 (ARK-1) is a centrosome-associated serine/threonine kinase that regulates centrosome separation, bipolar spindle assembly and chromosome segregation during mitosis. Bora (protein aurora borealis) is a 559 amino acid protein that activates ARK-1. Bora is localized to the nucleus until mitosis is initiated, when it then translocates to the cytoplasm. This translocation is dependent on activated Cdc2, which releases Bora to bind and activate ARK-1 in the cytoplasm. Plk (polo-like kinase) interacts with Bora to control the accessibility of its activation loop for phosphorylation and activation on its N-terminus by ARK-1. It is through this mechanism that Bora and ARK-1 control cellular mitotic entry. Downregulation of the gene encoding Bora results in multipolar spindles in mitosis, a phenomenon that is also observed when ARK-1 function is blocked.
Product Name Alternative
C13orf34
Swiss Prot
Q6PGQ7
Host
Rabbit
Reactivity
Human
Immunogen
Synthetic peptide of human BORA
Clonality
Polyclonal
Applications
WB, IHC
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Formulation
Purified antibody in PBS with 0.05% sodium azide and 50% glycerol.
Antibody Type
Primary antibody
Protein Name
BORA
Bands Size
61 kDa

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Alternative Products

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TA361862BORA Rabbit Polyclonal Antibody
NBP1-77013-0.025mgRabbit Polyclonal Bora Antibody
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NBP1-77346BRabbit Polyclonal Bora Antibody [Biotin]
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