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Rabbit Polyclonal Antibody to ALS2CL

CAT: 1725-P05811-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:1725-P05811-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Mutations in the ALS2 gene result in a number of juvenile recessive motor neuron diseases (MNDs), including juvenile primary lateral sclerosis (JPLS), a recessive form of amyotrophic lateral sclerosis (ALS2), infantile onset ascending hereditary spastic paralysis (IAHSP) and a form of complicated hereditary spastic paraplegia (cHSP) . The ALS2 gene encodes the Alsin protein. Alsin acts as a guanine nucleotide exchange factor for Rab5, a modulator of the endocytic pathway. Alsin is a cytosolic protein, which is associated with small, punctate membrane structures. Therefore Alsin may mediate membrane transport events, potentially linking endocytic processes and actin cytoskeleton remodeling. The ALS2 C-terminal like protein (ALS2CL) also modulates Rab5 activity.
Product Name Alternative
RN49018
Swiss Prot
Q60I27
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Synthetic peptide of human ALS2CL
Clonality
Polyclonal
Applications
IHC
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Formulation
Purified antibody in PBS with 0.05% sodium azide and 50% glycerol.
Antibody Type
Primary antibody
Protein Name
ALS2CL

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