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Rabbit Polyclonal Antibody to MOB1B

CAT: 1725-P04306-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:1725-P04306-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The protein encoded by this gene is similar to the yeast Mob1 protein. Yeast Mob1 binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation. Three transcript variants encoding different isoforms have been found for this gene. Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ.
Product Name Alternative
MATS2; MOB4A; MOBKL1A
Swiss Prot
Q7L9L4
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Synthetic peptide of human MOB1B
Clonality
Polyclonal
Applications
WB
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Formulation
Purified antibody in PBS with 0.05% sodium azide and 50% glycerol.
Antibody Type
Primary antibody
Protein Name
MOB1B
Bands Size
25 kDa

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