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Rabbit Polyclonal Antibody to CCM2

CAT: 1725-P02471-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:1725-P02471-01Size:50 µL
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Description
This gene encodes a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells. Mutations in this gene result in cerebral cavernous malformations. Multiple transcript variants encoding different isoforms have been found for this gene.
Product Name Alternative
OSM; C7orf22; PP10187
Swiss Prot
Q9BSQ5
Host
Rabbit
Reactivity
Human
Immunogen
Fusion protein of human CCM2
Clonality
Polyclonal
Applications
IHC
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Formulation
Purified antibody in PBS with 0.05% sodium azide and 50% glycerol.
Antibody Type
Primary antibody
Protein Name
CCM2