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Rabbit Polyclonal Antibody to PPM1A

CAT: 1725-P01660-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:1725-P01660-01Size:50 µL
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Description
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
Product Name Alternative
PP2CA; PP2Calpha; PP2C-ALPHA
Swiss Prot
P35813
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Fusion protein of human PPM1A
Clonality
Polyclonal
Applications
WB, IHC
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Formulation
Purified antibody in PBS with 0.05% sodium azide and 50% glycerol.
Antibody Type
Primary antibody
Protein Name
PPM1A
Bands Size
42 kDa