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Rabbit Polyclonal Antibody to DDIT4L

CAT: 1725-P01280-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:1725-P01280-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
REDD-2 (regulated in development and DNA damage response 2), also designated Rtp801L or DDIT4L (DNA-damage-inducible transcript 4-like), is a 193 amino acid cytoplasmic protein belonging to the DDIT4 family and is predominantly expressed in skeletal muscle. Considered a stress-inducted protein, REDD-2 is a negative regulator of the mTOR (mammalian target of rapamycin) pathway. mTOR is a serine/threonine kinase that plays an essential role in cell growth control and is an important regulator of skeletal muscle size. Highly expressed in human atherosclerotic lesions and macrophages, REDD-2 mediates monocyte cell death through reduction of Trx (thioredoxin-1) expression. REDD2 expression in macrophages increases oxidized LDL (oxLDL) -induced cell death, suggesting that REDD2 may play a critical role in arterial pathology.
Product Name Alternative
REDD2; Rtp801L
Swiss Prot
Q96D03
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Fusion protein of human DDIT4L
Clonality
Polyclonal
Applications
IHC
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Formulation
Purified antibody in PBS with 0.05% sodium azide and 50% glycerol.
Antibody Type
Primary antibody
Protein Name
DDIT4L

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