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Rabbit Polyclonal Antibody to STRAP

CAT: 1725-P08952-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:1725-P08952-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
STRAP (Serine-threonine kinase receptor-associated protein), also known as MAWD, is a ubiquitous WD40 domain protein, common function of which is to provide a suitable scaffold for coordinating multiprotein complex assemblies and thus, regulate a variety of cellular processes like signal transduction, transcriptional regulation, programmed cell death and so on. STRAP plays a role in the cellular distribution of the SMN complex, which is essential for spliceosomal snRNP assembly in the cytoplasm. STRAP inhibits transforming growth factor-beta (TGF-beta) signaling and enhances tumorigenicity via TGF-beta-dependent and -independent mechanisms. STRAP is up-regulated in several cancers and functions as an oncogene. STRAP imparts oncogenic characteristics to cells by promoting ERK and pRb phosphorylation. Moreover, STRAP regulates c-Jun stability by decreasing the ubiquitylation and proteosomal degradation of c-Jun.
Product Name Alternative
MAWD; PT-WD; UNRIP
Swiss Prot
Q9Y3F4
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Fusion protein of human STRAP
Clonality
Polyclonal
Applications
WB, IHC
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Formulation
Purified antibody in PBS with 0.05% sodium azide and 50% glycerol.
Antibody Type
Primary antibody
Protein Name
STRAP
Bands Size
38 kDa

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