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Rabbit Polyclonal Antibody to CHRDL2

CAT: 1725-P04776-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:1725-P04776-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CHRDL2 (chordin-related protein 2), also known as BNF1 (breast tumor novel factor 1) or CHL2 (chordin-like 2), is a 429 amino acid protein that belongs to the chordin family of proteins. CHRDL2 contains three VWFC (von Willebrand Factor type C) domains and is predominantly expressed in uterus and moderately expressed in prostate, liver, ovary, heart and testis. Due to alternative splicing events, CHRDL2 exists as five isoforms, namely isoform I, isoform II, isoform VII, isoform VIII and isoform IX. Two of these isoforms are secreted, while the other three localize to the cytoplasm. Functioning as a BMP-binding inhibitor, CHRDL2 directly interacts with BMPs and blocks their binding to BMP receptors, thereby inhibiting BMP activity. In breast, lung and colon tumors, CHRDL2 expression is upregulated, suggesting a possible role in tumorigenesis.
Product Name Alternative
BNF1; CHL2; FKSG37
Swiss Prot
Q6WN34
Host
Rabbit
Reactivity
Human
Immunogen
Synthetic peptide of human CHRDL2
Clonality
Polyclonal
Applications
WB, IHC
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Formulation
Purified antibody in PBS with 0.05% sodium azide and 50% glycerol.
Antibody Type
Primary antibody
Protein Name
CHRDL2
Bands Size
48 kDa