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Dihydromethysticin

CAT: 0804-HY-N0921-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N0921-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Dihydromethysticin is an orally active natural active ingredient. Dihydromethysticin can be extracted from Piper methysticum. Dihydromethysticin inhibits carboxylesterase 1 (Ki = 68.2 μM) and CYP2A5. Dihydromethysticin upregulates NLRC3 and induces Apoptosis. Dihydromethysticin exhibits anticancer activity against colorectal cancer and lung adenoma[1][2][3][4][5].
CAS Number
19902-91-1
Product Name Alternative
(+) -Dihydromethysticin
UNSPSC
12352005
Hazard Statement
H302
Target
Apoptosis; Carboxylesterase (CES) ; NOD-like Receptor (NLR)
Type
Natural Products
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Dihydromethysticin.html
Purity
99.94
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1C=C(OC)C[C@H](CCC2=CC=C(OCO3)C3=C2)O1
Molecular Formula
C15H16O5
Molecular Weight
276.29
Precautions
H302
References & Citations
[1]Pan H, et al. Dihydromethysticin, a natural molecule from Kava, suppresses the growth of colorectal cancer via the NLRC3/PI3K pathway. Mol Carcinog. 2020 Jun;59 (6) :575-589.|[2]Melchert PW, et al. In vitro inhibition of carboxylesterase 1 by Kava (Piper methysticum) Kavalactones. Chem Biol Interact. 2022 Apr 25;357:109883.|[3]Narayanapillai SC, et al. Dietary Dihydromethysticin Increases Glucuronidation of 4- (Methylnitrosamino) -1- (3-Pyridyl) -1-Butanol in A/J Mice, Potentially Enhancing Its Detoxification. Drug Metab Dispos. 2016 Mar;44 (3) :422-7.|[4]Hu Q, et al. Oral Dosing of Dihydromethysticin Ahead of Tobacco Carcinogen NNK Effectively Prevents Lung Tumorigenesis in A/J Mice. Chem Res Toxicol. 2020 Jul 20;33 (7) :1980-1988.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
CES1

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BA7247-5Dihydromethysticin
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