Calcium dextrofolinate

• Description :

  Calcium dextrofolinate is a stereoisomer of Calcium folinate. Calcium folinate (Folinic acid calcium) is a biological folic acid and is generally administered along with methotrexate (MTX) as a rescue agent to decrease MTX-induced toxicity[1].

• Product Name Alternative :

  (6R) -Leucovorin (calcium) ; (6R) -Folinic acid (calcium)

• UNSPSC :

  12352005

• Target :

  Drug Derivative

• Type :

  Reference compound

• Related Pathways :

  Others

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Metabolic Disease

• Assay Protocol :

  https://www.medchemexpress.com/calcium-dextrofolinate.html

• Purity :

  95.33

• Solubility :

  H2O : 1.96 mg/mL (ultrasonic; warming; adjust pH to 2 with 1 M HCL; heat to 60°C)

• Smiles :

  O=C([O-])CC[C@@H](C([O-])=O)NC(C1=CC=C(NC[C@H]2N(C=O)C3=C(N=C(N)NC3=O)NC2)C=C1)=O.[Ca+2]

• Molecular Formula :

  C20H21CaN7O7

• Molecular Weight :

  511.50

• References & Citations :

  [1]Shui-Jie Shen, et al. [Direct resolution of calcium folinate stereoisomers using a bovine serum albumin chiral HPLC column]. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2004 Jan;33 (1) :11-4.|[2]Keshava C, et al. Inhibition of methotrexate-induced chromosomal damage by folinic acid in V79 cells. Mutat Res. 1998 Feb 2;397 (2) :221-8.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C (Powder, protect from light, stored under nitrogen)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [115940-48-2]