Propranolol (hydrochloride) (Standard)

Propranolol (hydrochloride) (Standard)

• CAS Number: 318-98-9
• UNSPSC Description: Propranolol (hydrochloride) (Standard) is the analytical standard of Propranolol (hydrochloride). This product is intended for research and analytical applications. Propranolol hydrochloride is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with Ki values of 1.8 nM and 0.8 nM, respectively[1]. Propranolol hydrochloride inhibits [3H]-DHA binding to rat brain membrane preparation with an IC50 of 12 nM[2]. Propranolol hydrochloride is used for study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy[3].
• Target Antigen: Adrenergic Receptor; Bacterial
• Type: Reference Standards
• Related Pathways: Anti-infection;GPCR/G Protein;Neuronal Signaling
• Field of Research: Neurological Disease; Endocrinology; Cancer
• Assay Protocol: https://www.medchemexpress.com/propranolol-hydrochloride-standard.html
• Smiles: OC(CNC(C)C)COC1=CC=CC2=CC=CC=C12.Cl
• Molecular Weight: 295.80
• References & Citations: [1]Galandrin S, et al. Distinct signaling profiles of beta1 and beta2 adrenergic receptor ligands toward adenylyl cyclase and mitogen-activated protein kinase reveals the pluridimensionality of efficacy. Mol Pharmacol. 2006 Nov;70(5):1575-84. Epub 2006 Aug 1|[2]Briley M, et al. Evidence against beta-adrenoceptor blocking activity of diltiazem, a drug with calcium antagonist properties. Br J Pharmacol. 1980 Aug;69(4):669-73.|[3]Al-Majed AA, et al. Propranolol. Profiles Drug Subst Excip Relat Methodol. 2017;42:287-338.|[4]Munabi NC, et al. Propranolol Targets Hemangioma Stem Cells via cAMP and Mitogen-Activated Protein Kinase Regulation. Stem Cells Transl Med. 2016 Jan;5(1):45-55.
• Shipping Conditions: Room temperature