Lenalidomide-OH

• Description :

  Lenalidomide-OH is an analog of cereblon (CRBN) ligand Lenalidomide for E3 ubiquitin ligase, and is used in the recruitment of CRBN protein. Lenalidomide-OH can be connected to the ligand for protein by a linker to form PROTACs, such as the PROTAC BTK degrader SJF620 (HY-133137) [1].

• UNSPSC :

  12352005

• Hazard Statement :

  H315, H319, H335

• Target :

  Ligands for E3 Ligase

• Type :

  Reference compound

• Related Pathways :

  PROTAC

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/lenalidomide-oh.html

• Purity :

  99.48

• Solubility :

  DMSO : 13.89 mg/mL (ultrasonic)

• Smiles :

  O=C(C(N(CC1=C2C=CC(O)=C1)C2=O)CC3)NC3=O

• Molecular Formula :

  C13H12N2O4

• Molecular Weight :

  260.25

• Precautions :

  H315, H319, H335

• References & Citations :

  [1]Jaime-Figueroa S, et al. Design, synthesis and biological evaluation of Proteolysis Targeting Chimeras (PROTACs) as a BTK degraders with improved pharmacokinetic properties. 2020 Feb 1;30 (3) :126877.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  Cereblon

• CAS Number :

  [1416990-08-3]