Lenalidomide-OH

CAT: 0804-HY-133144-01Size: 100 mgDry Ice: NoHazardous: No
CAT#:0804-HY-133144-01Size:100 mg
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Description
Lenalidomide-OH is an analog of cereblon (CRBN) ligand Lenalidomide for E3 ubiquitin ligase, and is used in the recruitment of CRBN protein. Lenalidomide-OH can be connected to the ligand for protein by a linker to form PROTACs, such as the PROTAC BTK degrader SJF620 (HY-133137) [1].
CAS Number
[1416990-08-3]
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Ligands for E3 Ligase
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/lenalidomide-oh.html
Purity
99.48
Solubility
DMSO : 13.89 mg/mL (ultrasonic)
Smiles
O=C(C(N(CC1=C2C=CC(O)=C1)C2=O)CC3)NC3=O
Molecular Formula
C13H12N2O4
Molecular Weight
260.25
Precautions
H315, H319, H335
References & Citations
[1]Jaime-Figueroa S, et al. Design, synthesis and biological evaluation of Proteolysis Targeting Chimeras (PROTACs) as a BTK degraders with improved pharmacokinetic properties. 2020 Feb 1;30 (3) :126877.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon

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