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Desamino lenalidomide-7-OH

CAT: 0804-HY-W458077-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-W458077-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Desamino lenalidomide-7-OH is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. Desamino lenalidomide-7-OH can be linked to a target protein ligand via a linker to form a PROTAC.
CAS Number
1416990-10-7
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Ligands for E3 Ligase
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Purity
98.74
Smiles
O=C1NC(=O)C(N2C(=O)C=3C(O)=CC=CC3C2)CC1
Molecular Formula
C13H12N2O4
Molecular Weight
260.25
Precautions
H302, H315, H319, H335
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound2
Clinical Information
No Development Reported
Isoform
Cereblon

Chemical Information

3-(7-Hydroxy-1-oxoisoindolin-2-yl)piperidine-2,6-dione
CAS Number1416990-10-7
PubChem CID71517904
IUPAC Name3-(4-hydroxy-3-oxo-1H-isoindol-2-yl)piperidine-2,6-dione
Molecular FormulaC13H12N2O4
Molecular Weight260.24
XLogP0.4
Topological Polar Surface Area86.7
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count1
Heavy Atom Count19
Formal Charge0
Complexity436
SMILES
C1CC(=O)NC(=O)C1N2CC3=C(C2=O)C(=CC=C3)O
InChI
InChI=1S/C13H12N2O4/c16-9-3-1-2-7-6-15(13(19)11(7)9)8-4-5-10(17)14-12(8)18/h1-3,8,16H,4-6H2,(H,14,17,18)
InChIKey
ZHINEOZMGPJDNM-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 3-(7-Hydroxy-1-oxoisoindolin-2-yl)piperidine-2,6-dione
CAS: 1416990-10-7
CID: 71517904
Formula: C13H12N2O4
MW: 260.24
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight260.24
XLogP30.4
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count1
Exact Mass260.07970687
Monoisotopic Mass260.07970687
Topological Polar Surface Area86.7 Ų
Heavy Atom Count19
Formal Charge0
Complexity436
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
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Alternative Products

CatalogName
GTR19277423-01Desamino lenalidomide-4-Br-7-OH
GTR19275204-01Desamino lenalidomide-7-F
GTR19276632-01Desamino lenalidomide-7-CO
GTR19276415-01Desamino lenalidomide-7-propyne
GTR19276832-01Desamino lenalidomide-piperidine-C-OH
GTR19275354-01Desamino lenalidomide-NO2
GTR19276231-01Desamino lenalidomide-COOH
GTR19275829-017-F-4-I-Desamino lenalidomide
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GTR19276200-01Desamino lenalidomide-piperidin-piperazine

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