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TRAP-14 amide

CAT: 0931-TP3749-01Size: 10 mgDry Ice: NoHazardous: No
CAT#: TP3749-01Size: 10 mg
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AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
141923-36-6
Target
Protease-activated Receptor|||MMP|||Integrin
Related Pathways
Cytoskeletal Signaling|||GPCR/G Protein|||Proteases/Proteasome
Bioactivity
TRAP-14 amide is a protease-activated receptor (PAR) activating peptide and acts as a PAR agonist, with an EC50 of 24 ?M. It induces significant platelet aggregation via ADP and MMP-2 dependent pathways and is insensitive to Aspirin. Additionally, TRAP-14 amide effectively increases the surface expression of glycoprotein (GP) Ib and GPIIb/IIIa, as well as the release of ADP.
Smiles
C([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC1=CC=CC=C1)NC([C@H](CO)N)=O)=O)CC(C)C)=O)CC(C)C)=O)CCCNC(=N)N)=O)CC(N)=O)(=O)N2[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC3=CC=C(O)C=C3)C(N[C@H](C(=O)N4[C@H](C(N[C@@H](CC5=CC=CC=C5)C(N)=O)=O)CCC4)CCC(O)=O)=O)=O)CCCCN)=O)CC(O)=O)=O)CC(N)=O)=O)CCC2
Molecular Formula
C81H119N21O22
Molecular Weight
1738.94
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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