TRAP-1

• Target:

  Apoptosis|||Autophagy

• Related Pathways:

  Apoptosis|||Autophagy

• Bioactivity:

  TRAP-1 (XJZ-06-462) is a p53 transcription activator that effectively activates mutant p53 and triggers the transcription of p53 target genes. In the p53Y220C pancreatic cell line, TRAP-1 rapidly upregulates p21 and other p53 target genes. TRAP-1 also inhibits cell proliferation, exhibiting IC50 values of 3.94 ?M and 0.531 ?M in BxPC-3 and A549 cell lines, respectively. Additionally, TRAP-1 modulates autophagy in lung cancer cells and provides protection against oxidative stress and apoptosis.

• Molecular Formula:

  C57H66ClF3N11O3PS

• Molecular Weight:

  1108.69

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C