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Peptide R54

CAT: 0931-TP3693-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-TP3693-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
CXCR
Related Pathways
GPCR/G Protein, Autophagy, Immunology/Inflammation
Bioactivity
Peptide R54 (Pep R54; CXCR4 antagonist peptide 19) is an antagonistic polypeptide targeting CXCR4, known for its significant anticancer properties. It inhibits CXCR4-dependent cell migration, epithelial-mesenchymal transition, and the development of lung metastasis, offering better serum stability and higher CXCR4 affinity (IC50=20 nM) compared to the lead compound. Peptide R54 works synergistically with anti-PD-1 therapy to exhibit antitumor effects in vivo, enhancing granzyme activity and reducing Foxp3 cell infiltration. It is useful for research in colon cancer, ovarian cancer, and melanoma.
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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