(RXR) 4XB

CAT: 0931-TP3654-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-TP3654-01Size:10 mg
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CAS Number
879010-15-8
Target
Antibacterial
Related Pathways
Microbiology/Virology
Bioactivity
(RXR) 4XB is a cell-penetrating peptide that binds to phosphorodiamidate morpholino oligomer (PMO), resulting in a peptide-conjugated PMO (PPMO) and enhancing the delivery of PMO into bacterial cells. The (RXR) 4XB-PMO conjugate prevents biofilm formation, inhibits Pseudomonas aeruginosa (with an MIC50 of 0.5-16 ?M), and reduces bacterial load in a mouse acute pneumonia model.
Smiles
[C@@H](NC([C@@H](NC(CCCCCNC([C@@H](NC([C@@H](NC(CCCCCNC([C@H](CCCNC(=N)N)N)=O)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)=O)CCCNC(=N)N)=O)(C(NCCCCCC(N[C@H](C(N[C@H](C(NCCCCCC(N[C@H](C(NCCCCCC(NCCC(O)=O)=O)=O)CCCNC(=N)N)=O)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)=O)CCCNC(=N)N
Molecular Formula
C81H158N38O15
Molecular Weight
1904.37
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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