(RXR) 4XB

• Target :

  Antibacterial

• Related Pathways :

  Microbiology/Virology

• Bioactivity :

  (RXR) 4XB is a cell-penetrating peptide that binds to phosphorodiamidate morpholino oligomer (PMO), resulting in a peptide-conjugated PMO (PPMO) and enhancing the delivery of PMO into bacterial cells. The (RXR) 4XB-PMO conjugate prevents biofilm formation, inhibits Pseudomonas aeruginosa (with an MIC50 of 0.5-16 ?M), and reduces bacterial load in a mouse acute pneumonia model.

• Smiles :

  [C@@H](NC([C@@H](NC(CCCCCNC([C@@H](NC([C@@H](NC(CCCCCNC([C@H](CCCNC(=N)N)N)=O)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)=O)CCCNC(=N)N)=O)(C(NCCCCCC(N[C@H](C(N[C@H](C(NCCCCCC(N[C@H](C(NCCCCCC(NCCC(O)=O)=O)=O)CCCNC(=N)N)=O)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)=O)CCCNC(=N)N

• Molecular Formula :

  C81H158N38O15

• Molecular Weight :

  1904.37

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  879010-15-8