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CPI1

CAT: 0931-TP3085-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-TP3085-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
P-gp
Related Pathways
Neuroscience, Membrane transporter/Ion channel
Bioactivity
CPI1 is an effective and highly specific inhibitor of multidrug resistance protein 1 (MRP1) . It exhibits inhibitory activity against MRP1 at the nanomolar level (Ki: 100 nM) and has minimal effect on P-glycoprotein (Pgp) . CPI1 competes with LTC4 for binding to the same site on MRP1, inhibiting ATP hydrolysis and substrate transport. It is useful in research related to drug delivery and addressing cancer chemotherapy resistance.
Smiles
C[C@H]([C@H]1C(=O)N[C@@H](CSCC(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CO)CC(=O)O)CC2=CC=CC=C2)CCC(=O)N)CCC(=O)O)CC3=CC=C(C=C3)O)CC4=CC=C(C=C4)O)CC5=CNC6=CC=CC=C65)CC7=CNC=N7)CC(C)C)CC(=O)N)CC8=CNC9=CC=CC=C98)CC1=CC=CC=C1)CC1=CC=C(C=C1)O)C(=O)O)O
Molecular Formula
C111H131N23O30S
Molecular Weight
2299.43
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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