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A11

CAT: 0931-TP2685-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-TP2685-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2412926-29-3
Target
Annexin A, Ephrin Receptor
Related Pathways
Tyrosine Kinase/Adaptors, GPCR/G Protein
Bioactivity
A11 (ANXA1-derived 11 amino acid–long peptide) serves as an inhibitor of the ANXA1-EphA2 interaction, reducing ANXA1 attachment to EphA2 while promoting the association of Cbl (an E3 ubiquitin ligase of EphA2) with EphA2. This peptide also effectively lowers EphA2 levels, greatly enhances EphA2 ubiquitination, and stimulates EphA2 internalization along with the colocalization of EphA2 and Cbl in nasopharyngeal carcinoma (NPC) cells. Moreover, A11 curtails NPC cell proliferation, migration, and invasion, and it suppresses angiogenesis.
Smiles
[C@H](CC1=CC=C(O)C=C1)(C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(O)=O)=O)CCCCN)=O)CO)=O)CO)=O)CCCCN)=O)[C@@H](C)C)=O)[C@@H](C)O)=O)CCC(N)=O)=O)C(C)C)=O)NC([C@H](CCC(O)=O)N)=O
Molecular Formula
C53H88N14O19
Molecular Weight
1225.35
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

H-Glu-Tyr-Val-Gln-Thr-Val-Lys-Ser-Ser-Lys-Gly-OH
CAS Number2412926-29-3
PubChem CID171714357
IUPAC Name(4S)-4-amino-5-[[(2S)-1-[[(2S)-1-[[(2S)-5-amino-1-[[(2S,3R)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-(carboxymethylamino)-1-oxohexan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-1-oxohexan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-5-oxopentanoic acid
Molecular FormulaC53H88N14O19
Molecular Weight1225.3
XLogP-9.9
Topological Polar Surface Area568
Hydrogen Bond Donor Count20
Hydrogen Bond Acceptor Count22
Rotatable Bond Count42
Heavy Atom Count86
Formal Charge0
Complexity2270
SMILES
C[C@H]([C@@H](C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)O)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC1=CC=C(C=C1)O)NC(=O)[C@H](CCC(=O)O)N)O
InChI
InChI=1S/C53H88N14O19/c1-26(2)41(65-48(81)35(22-29-12-14-30(71)15-13-29)62-44(77)31(56)16-19-39(73)74)51(84)61-34(17-18-38(57)72)47(80)67-43(28(5)70)53(86)66-42(27(3)4)52(85)60-33(11-7-9-21-55)46(79)63-37(25-69)50(83)64-36(24-68)49(82)59-32(10-6-8-20-54)45(78)58-23-40(75)76/h12-15,26-28,31-37,41-43,68-71H,6-11,16-25,54-56H2,1-5H3,(H2,57,72)(H,58,78)(H,59,82)(H,60,85)(H,61,84)(H,62,77)(H,63,79)(H,64,83)(H,65,81)(H,66,86)(H,67,80)(H,73,74)(H,75,76)/t28-,31+,32+,33+,34+,35+,36+,37+,41+,42+,43+/m1/s1
InChIKey
SRSGQBYMCAHDHY-CQZPWPCGSA-N
Chemical Structure
2D Structure
2D structure of H-Glu-Tyr-Val-Gln-Thr-Val-Lys-Ser-Ser-Lys-Gly-OH
CAS: 2412926-29-3
CID: 171714357
Formula: C53H88N14O19
MW: 1225.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight1225.3
XLogP3-9.9
Hydrogen Bond Donor Count20
Hydrogen Bond Acceptor Count22
Rotatable Bond Count42
Exact Mass1224.63501663
Monoisotopic Mass1224.63501663
Topological Polar Surface Area568 Ų
Heavy Atom Count86
Formal Charge0
Complexity2270
Isotope Atom Count0
Defined Atom Stereocenter Count11
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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