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A11

CAT: 0931-TP2685-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-TP2685-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2412926-29-3
Target
Annexin A, Ephrin Receptor
Related Pathways
Tyrosine Kinase/Adaptors, GPCR/G Protein
Bioactivity
A11 (ANXA1-derived 11 amino acid–long peptide) serves as an inhibitor of the ANXA1-EphA2 interaction, reducing ANXA1 attachment to EphA2 while promoting the association of Cbl (an E3 ubiquitin ligase of EphA2) with EphA2. This peptide also effectively lowers EphA2 levels, greatly enhances EphA2 ubiquitination, and stimulates EphA2 internalization along with the colocalization of EphA2 and Cbl in nasopharyngeal carcinoma (NPC) cells. Moreover, A11 curtails NPC cell proliferation, migration, and invasion, and it suppresses angiogenesis.
Smiles
[C@H](CC1=CC=C(O)C=C1)(C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(O)=O)=O)CCCCN)=O)CO)=O)CO)=O)CCCCN)=O)[C@@H](C)C)=O)[C@@H](C)O)=O)CCC(N)=O)=O)C(C)C)=O)NC([C@H](CCC(O)=O)N)=O
Molecular Formula
C53H88N14O19
Molecular Weight
1225.35
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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