Dactinomycin

• Target:

  DNA/RNA Synthesis|||Autophagy|||Apoptosis|||Antibacterial|||Antibiotic

• Related Pathways:

  Microbiology/Virology|||DNA Damage/DNA Repair|||Cell Cycle/Checkpoint|||Apoptosis|||Autophagy

• Purity:

  0.997

• Bioactivity:

  Dactinomycin D (Actinomycin IV) is an antibiotic and autophagy activator produced by Streptomyces bacteria fermentation, which inhibits transcription and replication by inserting into the DNA double helix, and can also promote p53 phosphorylation and accumulation through MDM2 overexpression, serving as a chemotherapy drug for cancer treatment.

• Smiles:

  C(N[C@@H]1C(=O)N[C@H](C(C)C)C(=O)N2[C@@](CCC2)(C(=O)N(C)CC(=O)N(C)[C@@H]([C@@H](C)C)C(=O)O[C@@H]1C)[H])(=O)C=3C=4C(OC=5C(N4)=C(C(N[C@@H]6C(=O)N[C@H](C(C)C)C(=O)N7[C@@](CCC7)(C(=O)N(C)CC(=O)N(C)[C@@H]([C@H](C)C)C(=O)O[C@@H]6C)[H])=O)C=CC5C)=C(C)C(=O)C3N

• Molecular Formula:

  C62H86N12O16

• Molecular Weight:

  1255.42

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  50-76-0