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Talaroconvolutin A

CAT: 0931-TN11447-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-TN11447-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
273199-42-1
Target
ROS, p38 MAPK, Ferroptosis
Related Pathways
MAPK, Immunology/Inflammation, Apoptosis
Bioactivity
Talaroconvolutin A is an inducer of ferroptosis (ferroptosis) that operates by elevating reactive oxygen species (ROS) levels instead of acting through the GPX4 pathway. It decreases the expression of the solute carrier family 7 member 11 (SLC7A11) and increases the expression of arachidonate lipoxygenase 3 (ALOXE3) . This compound inhibits the growth of colorectal cancer cells HCT116 and bladder cancer cells SW480, with IC50 values of 1.22 μM and 1.4 μM, respectively. Talaroconvolutin A is applicable in studies related to colorectal and bladder cancers.
Smiles
C(=O)([C@H]1[C@]2([C@](C)(C=C(C)[C@H]1\C(=C\[C@H](CC)C)\C)C[C@H](C)CC2)[H])C3=C\C(=C\C4=CC=C(O)C=C4)\NC3=O
Molecular Formula
C32H41NO3
Molecular Weight
487.67
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Alternative Products

CatalogName
GTR19266244-01Talaroconvolutin A

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