TBK1/IKKε-IN-5
CAT:
804-HY-128679-04
Size:
100 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
TBK1/IKKε-IN-5
- CAS Number: 1893397-65-3
- UNSPSC Description: TBK1/IKKε-IN-5 (compound 1) is an orally active TBK1 and IKKε dual inhibitor, with IC50 values of 1 and 5.6 nM, respectively. TBK1/IKKε-IN-5 enhances the blockade response to PD-1 and induces immune memory in rats when combines with anti-PD-L1. TBK1/IKKε-IN-5 can be used in cancer research, especially in tumour immunity[1].
- Target Antigen: IKK
- Type: Reference compound
- Related Pathways: NF-κB
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/tbk1-ikk-epsilon-in-5.html
- Purity: 99.23
- Solubility: DMSO : 7.81 mg/mL (ultrasonic)
- Smiles: N#CC1=CC(C2=NC(NC3=CC=C(N4CCN(C5COC5)CC4)C=C3)=NC=N2)=CC=C1OC6CCOCC6
- Molecular Weight: 513.59
- References & Citations: [1]Jenkins RW, et al. Ex Vivo Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids. Cancer Discov. 2018 Feb;8(2):196-215.
- Shipping Conditions: Room Temperature
- Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
- Clinical Information: No Development Reported