LIX/CXCL5, Mouse (74a.a, CHO)

LIX/CXCL5, Mouse (74a.a, CHO)

• UNSPSC Description: CXCL5, also known as neutrophil activating peptide 78 (ENA‐78), is a CXC chemokine containing ELR motif. CXCL5 promotes angiogenesis through interaction with its specific receptor CXCR2. CXCL5 is expressed by many immune cells, such as macrophages, eosinophils, and non-immune cells including mesothelial cells, and fibroblasts.CXCL5/CXCR2 axis not only contributes to the recruitment of neutrophils but also regulates the function of neutrophils in melanoma[1][2]. LIX/CXCL5 Protein, Mouse (74a.a, CHO) is produced in CHO cells, and consists of 74 amino acids (V45-A118).
• Type: Recombinant Proteins
• Applications: COVID-19-immunoregulation
• Assay Protocol: https://www.medchemexpress.com/cytokines/lix-cxcl5-protein-mouse-74a-a-cho.html
• Purity: 98.0
• Smiles: VIAATELRCV CLTVTPKINP KLIANLEVIP AGPQCPTVEV IAKLKNQKEV CLDPEAPVIK KIIQKILGSD KKKA
• Molecular Weight: Approximately 8 kDa
• References & Citations: [1]Kawamura M, et al. CXCL5, a promoter of cell proliferation, migration and invasion, is a novel serum prognostic marker in patients with colorectal cancer. Eur J Cancer. 2012 Sep;48(14):2244-51.|[2]Kawamura M, et al. CXCL5, a promoter of cell proliferation, migration and invasion, is a novel serum prognostic marker in patients with colorectal cancer. Eur J Cancer. 2012 Sep;48(14):2244-51.|[3]Wen Zhang, et al. CXCL5/CXCR2 axis in tumor microenvironment as potential diagnostic biomarker and therapeutic target. Cancer Commun (Lond). 2020 Mar;40(2-3):69-80.|[4]Chun Chen, et al. CXCL5 induces tumor angiogenesis via enhancing the expression of FOXD1 mediated by the AKT/NF-κB pathway in colorectal cancer. Cell Death Dis. 2019 Feb 21;10(3):178.|[5]Junjie Mei, et al. CXCL5 regulates chemokine scavenging and pulmonary host defense to bacterial infection. Immunity. 2010 Jul 23;33(1):106-17.|[6]Carine Chavey, et al. CXC ligand 5 is an adipose-tissue derived factor that links obesity to insulin resistance. Cell Metab. 2009 Apr;9(4):339-49.
• Shipping Conditions: Blue Ice
• Storage Conditions: Stored at -20°C for 2 years