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VQW-765

CAT: 0804-HY-19490-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-19490-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
VQW-765 (AQW-051) is a selective and orally active alpha-7 nicotinic acetylcholine receptor (α7-nAChR) agonist with a pKD value of 7.56 to recombinantly expressed human α7-nAChR. VQW-765 shows anxiolytic-like effect in vivo. VQW-765 can be used for the research of anxiety disorder and acute performance anxiety[1].
CAS Number
669770-29-0
Product Name Alternative
AQW-051
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
NAChR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/vqw-765.html
Purity
99.58
Solubility
DMSO : 16.67 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
CC1=CC=C(C2=CC=C(O[C@H]3CN4CCC3CC4)C=N2)C=C1
Molecular Formula
C19H22N2O
Molecular Weight
294.40
Precautions
H315, H319, H335
References & Citations
[1]Feuerbach D, et al. AQW051, a novel, potent and selective α7 nicotinic ACh receptor partial agonist: pharmacological characterization and phase I evaluation. Br J Pharmacol. 2015 Mar;172 (5) :1292-304.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 2

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