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PP5-IN-2

CAT: 0931-T89967-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T89967-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
Phosphatase
Related Pathways
Metabolism
Bioactivity
PP5-IN-2, a selective and orally active inhibitor of protein phosphatase 5 (PP5), exhibits an IC 50 of 0.9 μM. This compound activates p53 and leads to the downregulation of cyclin D1 and MGMT, thereby inducing cell cycle arrest and reversing Temozolomide (TMZ) resistance in the U87 MG cell line. Additionally, PP5-IN-2 has demonstrated effective inhibition of tumor growth in the xenograft mouse model.
Molecular Formula
C16H15NO4
Molecular Weight
285.29
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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