Products for Research Use Only

SMART1

CAT: 0931-T89879-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T89879-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Target
Akt, PROTACs, Ras, PDK, Kras
Related Pathways
Cytoskeletal Signaling, MAPK, PROTAC, PI3K/Akt/mTOR signaling
Bioactivity
SMART1 is a CRBN-dependent PROTAC with high specificity that effectively degrades Smurf1. It inhibits tumor growth in xenograft models of colorectal cancer (CRC) with KRAS mutations and blocks the PDK1-Akt signaling pathway in KRAS-mutated colorectal cancer.
Molecular Formula
C40H35N9O7
Molecular Weight
753.76
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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