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TST1N-224

CAT: 0931-T89489-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T89489-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
50566-97-7
Bioactivity
TST1N-224 is an effective VraRC inhibitor that disrupts the formation of the VraRC-DNA complex (IC50=60.2 μM) . It interferes with the binding of VraRC to its homologous DNA through a rapid binding mechanism (KD=23.4 μM) and primarily interacts with the DNA binding domain helices α9 and α10 of VraR. TST1N-224 inhibits the growth of Staphylococcus aureus (SA; MIC>126 μM), methicillin-resistant Staphylococcus aureus (MRSA; MIC>126 μM), and vancomycin-intermediate Staphylococcus aureus (VISA; MIC=63 μM) . As an antimicrobial, TST1N-224 significantly enhances the sensitivity of VISA to vancomycin and methicillin.
Smiles
O=S(=O)(O)CCOCC1SSC(COCCS(=O)(=O)O)CSSC1
Molecular Formula
C10H20O8S6
Molecular Weight
460.65
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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