TST1N-224

• Bioactivity:

  TST1N-224 is an effective VraRC inhibitor that disrupts the formation of the VraRC-DNA complex (IC50=60.2 ?M) . It interferes with the binding of VraRC to its homologous DNA through a rapid binding mechanism (KD=23.4 ?M) and primarily interacts with the DNA binding domain helices ?9 and ?10 of VraR. TST1N-224 inhibits the growth of Staphylococcus aureus (SA; MIC>126 ?M), methicillin-resistant Staphylococcus aureus (MRSA; MIC>126 ?M), and vancomycin-intermediate Staphylococcus aureus (VISA; MIC=63 ?M) . As an antimicrobial, TST1N-224 significantly enhances the sensitivity of VISA to vancomycin and methicillin.

• Smiles:

  O=S (=O) (O) CCOCC1SSC (COCCS (=O) (=O) O) CSSC1

• Molecular Formula:

  C10H20O8S6

• Molecular Weight:

  460.65

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  50566-97-7