BC-1901S

• Target:

  Nrf2|||E1/E2/E3 Enzyme

• Related Pathways:

  Immunology/Inflammation|||Ubiquitination

• Bioactivity:

  BC-1901S functions as a proteasome-independent activator and stabilizer of NRF2. By binding to DCAF1 (E3 ligase subunit), it disrupts the NRF2/DCAF1 interaction and activates NRF2 through the inhibition of NRF2 ubiquitination, independent of KEAP1. BC-1901S has demonstrated anti-inflammatory effects in a murine model of LPS-induced acute lung injury.

• Smiles:

  O=C (NC1=CC=C (F) C (Cl) =C1) C2CCN (C3=NC (=NC=C3) C=4C=CC=C (C4) C) CC2

• Molecular Formula:

  C23H22ClFN4O

• Molecular Weight:

  424.9

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1358617-36-3