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BC-1901S

CAT: 0931-T87995-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T87995-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1358617-36-3
Target
Nrf2, E1/E2/E3 Enzyme
Related Pathways
Immunology/Inflammation, Ubiquitination
Bioactivity
BC-1901S functions as a proteasome-independent activator and stabilizer of NRF2. By binding to DCAF1 (E3 ligase subunit), it disrupts the NRF2/DCAF1 interaction and activates NRF2 through the inhibition of NRF2 ubiquitination, independent of KEAP1. BC-1901S has demonstrated anti-inflammatory effects in a murine model of LPS-induced acute lung injury.
Smiles
O=C(NC1=CC=C(F)C(Cl)=C1)C2CCN(C3=NC(=NC=C3)C=4C=CC=C(C4)C)CC2
Molecular Formula
C23H22ClFN4O
Molecular Weight
424.9
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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