OX-201

CAT: 0931-T89158-02Size: 50 mgDry Ice: NoHazardous: No

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CAT#:0931-T89158-02Size:50 mg

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CAS Number

2460722-03-4

Bioactivity

OX-201 is a selective agonist for OX2R with an EC50 of 8 nM. Pathological proteins produced by neurons are released into the interstitial fluid (ISF) in a neural activity-dependent manner and subsequently cleared from the brain via lymphatic pathways. The efflux of these proteins to the ISF correlates with the wakeful state of neurons. OX-201 can induce neuronal awakening and enhance the release of tau into the hippocampal ISF. While it does not alter hippocampal tau levels, OX-201 has potential applications in Alzheimers disease (AD) related to sleep/wake cycle disturbances.

Smiles

C([C@@H]1N(C(C(C)(C)O)=O)CC(F)(F)[C@@H]1NS(C)(=O)=O)C2=C(F)C(=CC=C2)C3=CC(F)=CC(F)=C3

Molecular Formula

C22H23F5N2O4S

Molecular Weight

506.49

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Chemical Information

Heb5WT4qzt

CAS Number	2460722-03-4
PubChem CID	154617485
IUPAC Name	N-[(2S,3R)-2-[[3-(3,5-difluorophenyl)-2-fluorophenyl]methyl]-4,4-difluoro-1-(2-hydroxy-2-methylpropanoyl)pyrrolidin-3-yl]methanesulfonamide
Molecular Formula	C22H23F5N2O4S
Molecular Weight	506.5
XLogP	3.2
Topological Polar Surface Area	95.1
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	10
Rotatable Bond Count	6
Heavy Atom Count	34
Formal Charge	0
Complexity	843

SMILES

CC(C)(C(=O)N1CC([C@@H]([C@@H]1CC2=C(C(=CC=C2)C3=CC(=CC(=C3)F)F)F)NS(=O)(=O)C)(F)F)O

InChI

InChI=1S/C22H23F5N2O4S/c1-21(2,31)20(30)29-11-22(26,27)19(28-34(3,32)33)17(29)9-12-5-4-6-16(18(12)25)13-7-14(23)10-15(24)8-13/h4-8,10,17,19,28,31H,9,11H2,1-3H3/t17-,19+/m0/s1

InChIKey

YMQLLGTTWOCIJB-PKOBYXMFSA-N

Chemical Structure

2D Structure

CAS: 2460722-03-4

CID: 154617485

Formula: C22H23F5N2O4S

MW: 506.5

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	506.5
XLogP3	3.2
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	10
Rotatable Bond Count	6
Exact Mass	506.12986920
Monoisotopic Mass	506.12986920
Topological Polar Surface Area	95.1 Å²
Heavy Atom Count	34
Formal Charge	0
Complexity	843
Isotope Atom Count	0
Defined Atom Stereocenter Count	2
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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OX-201

Chemical Information

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